Titlebook: Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis; Paolo Beck-Peccoz Textbook 2004 Kluwer Academic Publishers 200

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Pituitary Resistance to Thyroxine Action Due to a Defect in the Type 2 Deiodinase,mith demonstrated that the atrophic thyroid gland of hypophysectomized tadpoles underwent hypertrophy following administration of bovine anterior pituitary extract (1). Comparable findings in rats were reported in 1926 (2). Five years later, despite the severe limitations posed by the absence of sen

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Wallow

Tissues Specific Action of Thyroid Hormones: Insights from Knock out Animal Models,ich either the production of thyroid hormone or the function of thyroid hormone receptors (TRs) and related products is defective. These models begin to provide helpful information to understand the molecular basis of thyroid hormones action ..

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,Multi-Factorial Regulation of , Action of TRβ Mutants. Lessons Learned from RTH Mice with a Targeteentified in the TRβ gene of one kindred (2) and a Gly345rg mutation in another (3), establishing that mutations of the TRβ gene cause RTH. To date, about 100 different mutations in the TRβ gene have been reported in more than 300 families (4).

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Textbook 2004argely stems from the studies on the various syndromes of resistance to the hormones involved in the function of the axis. These syndromes essentially encompass two forms, i. e. the resistance to thyroid hormones and that to TSH action. The contribution of molecular biology has been fundamental in u

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Basal-Ganglia

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Michelina Plateroti,Cristina Angelin-Duclos,Frederic Flamant,Jacques Samaruttheir latest e- dite offerings which no one had ever thought of before. If such a time did once - ist, it certainly does so no longer. Writing a scientific or scholarly book in our era is to a large extent a team effort in which your team members are continually changing and you are unceasingly grat

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