| 书目名称 | Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis | | 编辑 | Paolo Beck-Peccoz | | 视频video | | | 概述 | Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis is a tour de force by experts in the field..Using clinical syndromes of thyroid hormone and TSH resistance, they explore the | | 丛书名称 | Endocrine Updates | | 图书封面 |  | | 描述 | The exponential growth in our knowledge on the pathophysiology of hypothalamic-pituitary-thyroid axis and, in particular, of thyroid hormone action, largely stems from the studies on the various syndromes of resistance to the hormones involved in the function of the axis. These syndromes essentially encompass two forms, i. e. the resistance to thyroid hormones and that to TSH action. The contribution of molecular biology has been fundamental in understanding the etiology of these different thyroid disorders and led to the discovery of new pathogenetic mechanisms, e. g. the dominant negative effects of a mutant protein on the normal one. In this book, I have assembled an internationally renewed group of experts devoted to the studies of both basic and clinical thyroidology. Taking the syndromes of resistance as a template, the novelties on the mechanisms of action of the various hormones, the etiopathogenesis of the syndromes, the instruments for the diagnosis, as well as the pitfalls in managing these diseases, are deeply revisited. The insights from different animal models are discussed, with particular focus on tissue specific action of thyroid hormones, as well as on the still e | | 出版日期 | Textbook 2004 | | 关键词 | hormone; hormone resistance; receptor; thyroid hormone; tissue; diabetes | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4020-7852-1 | | isbn_softcover | 978-1-4757-1065-6 | | isbn_ebook | 978-1-4020-7852-1Series ISSN 1566-0729 | | issn_series | 1566-0729 | | copyright | Kluwer Academic Publishers 2004 |
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发表于 2025-3-21 18:06:56
