Titlebook: Superantigen Protocols; Teresa Krakauer Book 2003 Springer Science+Business Media New York 2003

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1064-3745 oning to toxic shock, but can also be used to understand these pathologies and devise therapeutic agents to combat them. In Superantigen Protocols, leading researchers in the biological, chemical, and physical investigation of superantigens describe in step-by-step detail their best experimental tec

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Superantigens,ate the host sufficiently through their effects on cells of the immune system to permit the causation of disease (.). Their superantigenic activity can be attributed to their ability to bind to both major histocompatibility complex (MHC) class II molecules and T cell receptors by forming a trimolecu

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Expression, Purification, and Detection of Novel Streptococcal Superantigens,eral surfaces of major histocompatibility (MHC) class II molecules on antigen presenting cells, and to particular variable regions of the T-cell antigen receptor (TCR) β-chain. Among the secreted virulence factors from group A streptococci are the streptococcal pyrogenic exotoxins (SPEs), also commo

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Flow Cytometric Detection of MMTV Superantigens,tigens, they interact with class II major histocompatiblity complex (MHC) proteins and trigger T-cell proliferation via recognition of particular variable elements (V.) of the T-cell receptor (TCR). Prior to the discovery of their viral origin, the provirus-encoded vSAgs were referred to as Mls (min

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Spectrophotometric Methods for the Determination of Superantigen Structure and Stability,s are stable enough to traverse the stomach while retaining their biological activity. Despite this high stability, structural flexibility may be a very important parameter to control their functions such as recognition of certain T-cell receptor (TCR) V.-chains. The biological properties of SAgs ar

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Directed Evolution of T-Cell Receptors for Binding Superantigens,ext of a major histocompatibility complex (pMHC) provides for the specificity of a cell-mediated immune response. However, this normal antigen recognition event can be circumvented by bacterial and viral proteins called superantigens (SAgs) (.). These unprocessed antigens bind to and thereby crossli