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Titlebook: Structure and Function of GPCRs; Guillaume Lebon Book 2019 Springer Nature Switzerland AG 2019 Aminoacids Incorporation.Class C GPRC activ

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NMR Spectroscopy for the Characterization of GPCR Energy Landscapes,losteric and signaling partners, is fundamental in order to gain a clear picture of how the signaling mechanism proceeds. Solution-state nuclear magnetic resonance (NMR) is a powerful technique to study GPCR energy landscapes, i.e., conformational ensembles along activation and inactivation pathway, and associated kinetic barriers.
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Endosomal PTH Receptor Signaling Through cAMP and Its Consequence for Human Medicine,omes. This model has been recognized as a new paradigm of GPCR signaling for peptide hormones, and the PTHR is a prototypical example. In this chapter we discuss molecular, structural, and cellular mechanisms responsible for this unexpected signaling process and its biological consequences.
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Topics in Medicinal Chemistryhttp://image.papertrans.cn/t/image/880201.jpg
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