| 书目名称 | Structure and Function of GPCRs |
| 编辑 | Guillaume Lebon |
| 视频video | |
| 概述 | Reviews the structural basis of ligand binding and allosteric mechanisms.Presents concrete examples of structure-based drug discovery.Illustrates GPCR biased signaling in physiological contexts |
| 丛书名称 | Topics in Medicinal Chemistry |
| 图书封面 |  |
| 描述 | This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the important concept of GPCR biased signaling in physiological contexts, and presents fluorescent- and light-based methodologies frequently used to measure GPCR signaling or to trace their dynamics in cells upon ligand activation. .Taken together, the chapters provide an essential overview and toolkit for new scientific investigators who plan to develop GPCR projects. All chapters were written by experts in their respective fields, and share valuable insights and powerful methodologies for the GPCR field.. |
| 出版日期 | Book 2019 |
| 关键词 | Aminoacids Incorporation; Class C GPRC activation mechanism; Endocytic Pathway; Femtosecond Crystallogr |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-030-24591-7 |
| isbn_ebook | 978-3-030-24591-7Series ISSN 1862-2461 Series E-ISSN 1862-247X |
| issn_series | 1862-2461 |
| copyright | Springer Nature Switzerland AG 2019 |
发表于 2025-3-21 17:52:07
