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Titlebook: Stress Response Pathways in Cancer; From Molecular Targe Georg T. Wondrak Book 2015 Springer Science+Business Media Dordrecht 2015 cancer b

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Introduction to Cell Stress Responses in Cancer: The Big Picture,ess response pathways enabling adaptive capabilities that antagonize the cytotoxic consequences of oncogenesis-associated cellular stresses, and cumulative research indicates that the essential nature of these stress response pathways represents a specific molecular vulnerability amenable to therape
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p53 at the Crossroads Between Stress Response Signaling and Tumorigenesis: From Molecular Mechanismion have placed p53 at the center of cancer investigation. Numerous cellular and mouse models have demonstrated that restoration of p53 function may stop tumor progression or even promote tumor regression. Now, these observations lead to the development of multiple anti-cancer therapeutic strategies
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The Hsp70 Family of Heat Shock Proteins in Tumorigenesis: From Molecular Mechanisms to Therapeutic itors of this family of molecular chaperones for cancer therapy. Here-in we review the pro-tumorigenic function(s) of this protein, our understanding of how HSP70 mediates protein quality control, and the current efforts to target and inhibit this protein for cancer therapy.
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