Titlebook: Stress Response Pathways in Cancer; From Molecular Targe Georg T. Wondrak Book 2015 Springer Science+Business Media Dordrecht 2015 cancer b

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Senescence in Oncogenesis: From Molecular Mechanisms to Therapeutic Opportunities,ally terminating in a quiescent but viable state now known as replicative senescence. These cells show clear and distinctive morphological, physiological and biochemical characteristics. Moreover, the senescent phenotype is associated with a typical gene-expression profile. Similar behaviour has sin

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Pro-senescence Therapy for Cancer: Time for the Clinic, senescence response, termed pre-mature senescence, driven by DNA-damage, oncogene over-expression or loss of tumour suppressor genes. Recent evidences demonstrate that cellular senescence occurs also in tumours, where it opposes tumour initiation and progression. Senescence cells secrete a variety

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Endoplasmic Reticulum Stress in Multiple Myeloma: From Molecular Mechanisms to Therapeutic Opportunulation of misfolded proteins in the ER leads to ER stress, which triggers the activation of three well-known pathways including activating inositol requiring kinase 1 (IRE1), the transcription factor activating transcription factor 6 (ATF6), and double stranded RNA-activated protein kinase-like ER

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Melanomagenic Gene Alterations Viewed from a Redox Perspective: Molecular Mechanisms and Therapeuti, and invasiveness of cancer cells has recently emerged. A large body of experimental and epidemiological research has substantiated the causative involvement of specific genetic alterations in melanomagenesis. Strikingly, some of the proteins encoded by specific genes underlying melanomagenesis (.,

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Targeting Hypoxic Adaptations of Cancer Cells: Molecular Mechanisms and Therapeutic Opportunities, metastasis, and chemoresistance. Given its central role in tumorigenesis, tumour hypoxia is an attractive therapeutic target. There are three main O.-sensing pathways, namely the unfolded protein response (UPR), the target of rapamycin kinase (mTOR), and the hypoxia-inducible factor-1 (HIF-1) pathw

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At the Crossroads Between Mitochondrial Metabolite Transport and Apoptosis: VDAC1 as an Emerging Caa great majority of cancer types. The voltage-dependent anion channel 1 (VDAC1), an outer mitochondria membrane protein, serves as a mitochondrial gatekeeper, controlling the metabolic and energy cross-talk between mitochondria and the rest of the cell. VDAC1 has also been recognized as a key protei