Titlebook: Store-Operated Ca²⁺ Entry (SOCE) Pathways; Emerging Signaling C Klaus Groschner,Wolfgang F. Graier,Christoph Roman Book 2017Latest edition

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The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modificationsange of chemical modifications besides their known role in disulfide formation, such as S-sulfenylation (-SOH), S-sulfinylation (-SO(2)H), S-sufonylation (-SO(3)H), S-glutathionylation (-SSG), and S-sulfhydration (-SSH), among others. These posttranslational modifications can be irreversible and act

DEI

The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channelsxpression, and metabolism. To study the impact of Ca. signals on biological processes, pharmacological tools and caged compounds have been commonly applied to induce fluctuations of intracellular Ca. concentrations. These conventional approaches, nonetheless, lack rapid reversibility and high spatio

教唆

STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexesle cells are the Orai and TRPC families of Ca. channels. These channels are activated in response to cell stimulation and Ca. release from the endoplasmic reticulum (ER). The protein that conveys the Ca. content of the ER to the plasma membrane is the ER Ca. sensor STIM1. STIM1 activates the Orai ch

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STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: ols the regulation of physiological functions in a wide variety of cell types. The transient receptor potential canonical (TRPC) channels (TRPCs 1–7), which are activated by stimuli leading to PIP. hydrolysis, were first identified as molecular components of SOCE channels. While TRPC1 was associated

通情达理

STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex the endoplasmic reticulum (the stores) and a calcium channel immersed on the plasma membrane. These two basic components are STIM and Orai, the most fundamental and minimal molecular constituents of the store-operated calcium entry mechanism. However, even when minimal components can be reduced to

绿州

OATH

New Aspects of the Contribution of ER to SOCE Regulation: The Role of the ER and ER-Plasma Membrane junctions have specific dimensions and are nonuniformly distributed in polarized cells. The mechanisms involved in the formation of the junctions are currently undergoing vigorous investigation, and significant progress was attained in this research area during the last 10 years. Some cell types di

Delude

约会

bifurcate

The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling nsing STIM proteins on the endoplasmic reticulum (ER) and Ca.-permeable ORAI channels on the plasma membrane (PM). STIM-ORAI interactions occur at membrane contact sites (MCS), evolutionarily conserved cellular structures characterized by the close apposition (10–20 nm) between the ER and target mem