Titlebook: Store-Operated Ca²⁺ Entry (SOCE) Pathways; Emerging Signaling C Klaus Groschner,Wolfgang F. Graier,Christoph Roman Book 2017Latest edition

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Alexei V. Tepikinassung wird abschließend in Abschn. 6.3, als exemplarisches Beispiel, ein konzeptueller Entwurf eines Prozessorkerns durchgeführt und dessen prototypische Implementierung in einem FPGA Baustein dargestellt. Darüber hinaus werden in Abschn. 6.4 die heute gebräuchlichen Verbindungstechnologien in prog

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The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operctivation of Orai1 channel activity. This unimolecular model is strongly supported by evidence of variable STIM1:Orai1 stoichiometry reported in many studies. We hypothesize that unimolecular coupling promotes cross-linking of channels, localizing Ca. signals, and regulating channel activity. We hav

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The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels and non-excitable cells. When combined with nanotechnology, it becomes feasible to wirelessly photo-modulate Ca.-dependent activities in vivo. In this chapter, we briefly review most recent advances in engineering CRAC channels to achieve optical control over Ca. signaling, outline their design pri

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STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: istinct domain in its C-terminus. However, TRPC1 function depends on Orai1-mediated Ca. entry, which triggers recruitment of TRPC1 into the plasma membrane where it is activated by STIM1. TRPC1 and Orai1 form distinct store-operated Ca. channels that regulate specific cellular functions. It is now c

AGONY

New Aspects of the Contribution of ER to SOCE Regulation: TRPC Proteins as a Link Between Plasma Memr store-operated Ca. entry, evidence is growing for STIM-operated TRPC channel activities in various cell types, demonstrating both store-dependent and store-independent mechanisms of TRPC channel gating. The existence of physical and functional interactions between plasma membrane-localized TRPC ch

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The Role of Mitochondria in the Activation/Maintenance of SOCE: Store-Operated Ca2+ Entry and MitochOCE is sensed by mitochondria, and the ensuing mitochondrial Ca. uptake boosts mitochondrial energy metabolism and, if Ca. overload occurs, may even lead to apoptosis or cell death. In several cell types, mitochondria seem to be sterically excluded from the confined space that forms between the plas

Generosity

The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling ed by the release of Ca. from acidic stores. Intracellular MCS also regulate the efficiency of phagocytosis, a fundamental cellular process essential for immunity and tissue homeostasis, by ensuring the coordinated opening of Ca. channels on phagocytic vacuoles and of Ca. release channels on juxtapo

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