Titlebook: Stem Cells in the Nervous System: Functional and Clinical Implications; Fred H. Gage,Anders Björklund,Yves Christen Conference proceedings

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Neurogenesis in Stroke and Epilepsy,ng the lateral ventricles. These findings raise the possibility that the adult brain tries to use its own stem cells to repair itself. New neurons generated by ischemic insults have now been shown to migrate from the subventricular zone and posterior periventricle to the damaged striatum and CA1 reg

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The Incorrect Use of Transcription Factors: A Key to Your (STEM) Cells?,acement therapies. Thus large numbers of studies are aimed at elucidating the sequence of signaling events leading from stem cells to the cells with the desired differentiated phenotype..Recently, we have observed that homeoprotein transcription factors have the uncanny property of transferring betw

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Astrocytic nature of adult neural stem cells in vivo,essarily derived from the in vivo primary precursors but from transit amplifying cells. We suggest that neural stem cells, when activated to become transit amplifying cells, upregulate the expression of growth factor receptors on their surface, allowing their isolation as neurospheres.

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Converting ES Cell into Neurons,ellular and molecular dissection of ES cell lineage choice may yield insights into the mechanism underlying neural determination in the mammalian embryo. This simple culture system is also a step towards the “directed,” homogeneous differentiation of ES cells required for biopharmaceutical and clinical applications.