Titlebook: Sphingolipid Biology; Yoshio Hirabayashi,Yasuyuki Igarashi,Alfred H. Mer Book 2006 Springer-Verlag Tokyo 2006 Activation.Lipid.base.biolog

LUMEN

Dihydroceramide: Sphinganine Δ4-Desaturase and C4-Hydroxylaseeramide has attracted attention because it is a signaling molecule involved in apoptosis. The genes for .-acylsphinganine, sphinganine ω4-desaturase and C4-hydroxylase, are responsible for the biosynthesis of ceramide and dihydroceramide. These genes were identified in 2002 through exhaustive search

Anthology

Metabolizing Enzymes Such As Sphingomyelin Synthase Induce Cell Death by Increasing Ceramide Contentecies (ROS) and c-jun-N-terminal kinase (JNK), and anti-apoptotic signals such as phosphatidylinositides (PI)-3 kinase and protein kinase C are inhibited by ceramide. Sphingosine-1-phosphate (S1P) competes with ceramide-induced cell death by blocking its generation and downstream pathways. This bala

MEAN

破译

Synthesis, Metabolism, and Trans-Bilayer Movement of Long-Chain Baseids but also as signaling molecules. LCBs can be converted to other bioactive lipid molecules, ceramide and long-chain base 1-phosphates (sphingosine 1-phosphate in mammals). In theory, the balance of these lipids determines cell fate (the sphingolipid rheostat model). Therefore, the regulation of t

攀登

有权

Sphingolipid Traffickingated by selective intracellular trafficking. Transport and sorting of sphingolipids between organelles occurs via vesicular and/or non-vesicular transport mechanisms. Some sphingolipids can also move between the two leaflets of the membrane lipid bilayer and their lateral mobility in the plane of th

听写

Current Perspectives on , Sphingolipidsoid long-chain bases, dihydrosphingosine and phytosphingosine, have gained prominence in yeast as regulators of the AGC-type protein kinase Pkh1 and Pkh2, homologs of mammalian phosphoinositide-dependent protein kinase 1 (PDK1). Pkh1 and Pkh2 activate the downstream kinases Pkc1, Ypk1, Ypk2 and Sch9

渗入

Generation of Signaling Molecules by De Novo Sphingolipid Synthesisis begins with condensation of L-serine and palmitoyl-CoA, generating sphingoid bases, ceramide, and other species through a series of reactions. Ceramide can also be formed from free sphingoid bases, which has been termed the’ salvage’ pathway. Sphingolipids from both the de novo and salvage pathwa

颂扬国家

chondromalacia

Neutral Ceramidase as an Integral Modulator for the Generation of S1P and S1P-Mediated Signalinge in zebrafish and mammals are typical type II integral membrane proteins that occasionally detach from cells after their NH.-terminal anchor is processed. We found that the difference in enzymatic localization is entirely due to the presence of a mucin-like domain located downstream of the NH.-term