Titlebook: Sphingolipid Biology; Yoshio Hirabayashi,Yasuyuki Igarashi,Alfred H. Mer Book 2006 Springer-Verlag Tokyo 2006 Activation.Lipid.base.biolog

无王时期,

freight

Serine Palmitoyltransferase; however, the SPT inhibitor myriocin has been found to decrease atherosclerotic lesions in apo-E deficient mice. SPT is clearly involved in critical cell functions and disease, and much remains to be learned about its regulation.

wangle

Synthesis, Metabolism, and Trans-Bilayer Movement of Long-Chain Base the LCB must be localized in a specific leaflet of the lipid bilayer. Thus, regulation of LCB trans-bilayer movement is also important. This review focuses on recent gains in our understanding of the synthesis, metabolism, and trans-bilayer movement of LCBs.

深渊

Molecular Mechanism of Ceramide Trafficking from the Endoplasmic Reticulum to the Golgi Apparatus insolated a mammalian cultured cell mutant defective in ceramide trafficking, and have recently identified a key factor (named CERT) for ceramide trafficking in functional rescue experiments and proposed a molecular lipid extraction and transfer model for the non-vesicular mechanism of CERT-mediated trafficking of ceramide.

infinite

Current Perspectives on , Sphingolipidsding growth, cell wall integrity, stress resistance, endocytosis and aging. Our appreciation of long-chain bases as second messengers will grow as we learn more about the processes controlled by AGC kinases as well as other yeast kinases that are likely to be regulated by long-chain bases.

不朽中国

Chandelier

Activation of Sphingosine Kinase 1so regulated by the translocation of SphK1 to membranes, where its substrate sphingosine is formed. SphK1 translocation to membranes can be mediated by interactions with lipids and proteins. Here we review the current knowledge of SphK1 activation and translocation.

N斯巴达人

Definitive

AER