| 书目名称 | Sperm Acrosome Biogenesis and Function During Fertilization | | 编辑 | Mariano G. Buffone | | 视频video | | | 概述 | Provides a broad perspective on understanding the molecular mechanisms governing the fertilization process.Covers the formation of the acrosome during spermatogenesis.Reviews the site of acrosomal exo | | 丛书名称 | Advances in Anatomy, Embryology and Cell Biology | | 图书封面 |  | | 描述 | .Over the last decades, acrosomal exocytosis (also called the “acrosome reaction”) has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reportedin neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing thi | | 出版日期 | Book 2016 | | 关键词 | acrosomal exocytosis; fertilization process; spermatogenesis; acrosome reaction; acrosomal matrix; sperm | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-30567-7 | | isbn_softcover | 978-3-319-30565-3 | | isbn_ebook | 978-3-319-30567-7Series ISSN 0301-5556 Series E-ISSN 2192-7065 | | issn_series | 0301-5556 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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发表于 2025-3-21 17:12:18
