Titlebook: Specificity, Function, and Development of NK Cells; NK Cells: The Effect Klas Kärre,Marco Colonna Book 1998 The Editor(s) (if applicable) a

GUISE

阐释

Ontogeny and Differentiation of Murine Natural Killer Cells and Their Receptorsted by destruction of bone marrow with the bone-seeking isotope .Sr (. and . 1971; . 1973). Thus these effector cells were termed “marrow-dependent” or M cells, based on the analogy with the thymus and bursa-dependent T and B cell. Later studies revealed that M cells are identical to natural killer (NK) cells.

缝纫

Natural Killer Cells and Tumor Therapymany biological agents, including cytokines such as interleukin (IL)-2 or IL-12 and inter-ferons (IFNs), and rapidly to increase their cytolytic, secretory, proliferative, and other functions upon stimulation with these agents (. et al. 1996; . et al. 1992).

构想

Regulation of Mouse NK Cells by Structurally Divergent Inhibitory Receptorses that promote an inflammatory immune response. NK cell specificity and the activation events resulting in NK cell stimulation remain poorly understood. However, from parallel studies in rodents and humans it is becoming increasingly evident that a major mode of NK cell specificity is through regul

Monolithic

beta-cells

使厌恶

The CD94/NKG2 C-Type Lectin Receptor Complex control of NK cell activity depends on a subtle balance between inhibitory and activating signals; accordingly, every mature NK cell should bear at least one type of dominant inhibitory receptor for a self MHC class I product, thus preventing autoreactivity against normal cells. Recognition of H-2

Critical

Triggering of Natural Killer Cell Mediated Cytotoxicity by Costimulatory Moleculesn several models target cell major histocompatibility complex (MHC) class I molecules have been demonstrated to be able to turn off NK cells (. and . 1990; . 1995) by delivering inhibitory signals to MHC class I binding receptors (. et al. 1992; . and . 1993). The latter include members of the Ly-49

Infiltrate

Fc Receptors on Natural Killer Cells target cells (reviewed in . 1989). The receptor(s) involved in binding/recognition of target cells sensitive to spontaneous cytotoxicity (i.e., that mediated by NK cells from healthy nonimmunized individuals against nonsensitized targets) remain elusive. Target cells not bound spontaneously by NK c

浪荡子

Adhesion in NK Cell Functionreshly isolated lymphocytes. The adhesion molecule expression of NK cells is altered by activation. Both high-affinity conformation of β.-integrins and upregulation of various adhesion molecules takes place, especially after the stimulation with interleukin (IL) 2.