Titlebook: Specificity, Function, and Development of NK Cells; NK Cells: The Effect Klas Kärre,Marco Colonna Book 1998 The Editor(s) (if applicable) a

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978-3-642-46861-2The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE

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Specificity, Function, and Development of NK Cells978-3-642-46859-9Series ISSN 0070-217X Series E-ISSN 2196-9965

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Current Topics in Microbiology and Immunologyhttp://image.papertrans.cn/s/image/873788.jpg

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https://doi.org/10.1007/978-3-642-46859-9Infektion; Krebs; Krebstherapie; MHC; NK cells; cancer; cancer therapy; cell; cytotoxicity; infection; inhibit

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Regulation of Mouse NK Cells by Structurally Divergent Inhibitory Receptorsod. However, from parallel studies in rodents and humans it is becoming increasingly evident that a major mode of NK cell specificity is through regulation of NK cell activation by a series of inhibitory receptors specific for MHC class I molecules.

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Book 1998C class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules. Such recog

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Killer Cell Inhibitory Receptor Expression by T Cellsss I ligands can modulate T cell function in a manner comparable to that observed for NK cells. This contribution summarizes recent advances in understanding the functional significance of T cell expression of KIR family members.