| 书目名称 | Specialization and Complementation of Humoral Immune Responses to Infection |
| 编辑 | Tim Manser |
| 视频video | |
| 概述 | Includes supplementary material: |
| 丛书名称 | Current Topics in Microbiology and Immunology |
| 图书封面 |  |
| 描述 | The importance of specific antibodies for the clearance of and long-term resistance to many infectious pathogens has long been appreciated. Moreover, the role in these processes of the different antibody heavy chain isotypes, each tailored to induce diverse effector pathways such as those mediated by complement and Fc receptors and to promote antibody localization in distinct regions of the body, is well established. Insights into the molecular mechanism of isotype class switching showed that during an immune response B cells could change the heavy chain of the antibody they produced, without influencing the structure and specificity of the antigen-binding variable regions of this antibody (Honjo 1983). More recently, the germinal center pathway of B cell development was elucidated, in which antibody variable regions undergo extensive structural alteration via hypermutation followed by stringent phenotypic selection (Berek 1992; Kelsoe 1995). Emerging from this pathway are memory B cells and long-lived antibody-forming cells that express antigen receptors and secrete antibodies, respectively, with increased affinity and specificity for the foreign antigen. Taken together, these fin |
| 出版日期 | Book 2008 |
| 关键词 | Antigen; B cells; T cells; bacteria; borrelia infection; complement; immunization; infection; infections; inf |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-540-73900-5 |
| isbn_softcover | 978-3-642-09313-5 |
| isbn_ebook | 978-3-540-73900-5Series ISSN 0070-217X Series E-ISSN 2196-9965 |
| issn_series | 0070-217X |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
发表于 2025-3-21 17:26:49
