Titlebook: Sodium and Water Homeostasis; Comparative, Evoluti Kelly Anne Hyndman,Thomas L. Pannabecker Book 2015 American Physiological Society 2015 A

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Overview, large salty meal, the body has to regulate salts and water to maintain in balance. This book highlights recent advances in the fields of comparative, evolutionary and genetic models of sodium and water homeostasis in an attempt to encourage collaboration and discussion among comparative and biomedi

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Use of Genetic Models to Study the Urinary Concentrating Mechanism,intained, or dysfunctional in certain diseases is thus of clinical importance. In recent years, application of transgenic and knockout mouse technology is providing critical new information about urinary concentrating processes and thus mechanisms for maintaining body water homeostasis. In this chap

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The Evolution and Comparative Physiology of Endothelin Regulation of Sodium Transport,tion of vascular tone and in the mammalian kidney they function to inhibit sodium reabsorption. Much of our understanding of endothelin-1 (ET1) signaling comes from studies in rodents; however, the endothelins and the endothelin receptors have an interesting evolutionary history, having evolved in t

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Genetic Manipulation of the Endothelin System,n converting enzymes (ECE). These peptides exert a wide variety of physiological and pathophysiological effects by activating a pair of classical G-protein coupled receptors, ET. and ET.. Genetic manipulation of the ET system in rodents has revealed an important role of this system on fetal organ de

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Go with the Flow: Fluid Roles for miRNAs in Vertebrate Osmoregulation, salt and water balance, miRNAs enable precise control over osmoregulatory processes in vertebrates. Differential expression of miRNAs and divergent mRNA targeting have allowed for adaptation of osmoregulatory tissues during vertebrate evolution. Interestingly, only a small number of mRNA target rel

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