Titlebook: Sodium and Water Homeostasis; Comparative, Evoluti Kelly Anne Hyndman,Thomas L. Pannabecker Book 2015 American Physiological Society 2015 A

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Renal Medullary Functional Architecture and the Urinary Concentrating Mechanism,the chief mechanisms by which the kidney maintains salt and water balance. Many underlying principles of fluid and solute transport in nephrons and blood vessels are understood to some extent; but how fluid and solute movements throughout the renal medulla are integrated into a unified mechanism for

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Non-traditional Models: The Giraffe Kidney from a Comparative and Evolutionary Biology Perspective,ney function in this extraordinary animal obtained over the course of two major expeditions in 2010 and 2012. As expected, the anaesthetised giraffes had very high mean arterial blood pressure ranging between 150 and 300 mmHg. However, despite the high filtration pressure, the rate of glomerular fil

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Non-traditional Models: The Molecular Physiology of Sodium and Water Transport in Mosquito Malpighiuid secretion. Here we summarize the current state of knowledge on the cellular and molecular mechanisms of sodium and water transport in the tubule epithelium, and highlight key areas in which further research is needed. In brief, the epithelium contains several mechanisms for the transport of sodi

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Circadian Rhythms of Ion Transporters in the Visual System of Insects, and glial cells of the visual system of Diptera. In the optic lobe of two fly species, . and ., significant changes in the abundance of two major types of membrane pumps, the sodium pump (Na./K.-ATPase) and the vacuolar proton pump (V-ATPase) have been observed in the 24 h day/night cycle. These os

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The Circadian Clock in the Mammalian Kidney,ption factors that regulate gene expression in the kidney and in nearly all other organs and cell types. Modulation of clock genes can cause major physiological effects. Loss of any of the core clock genes in mice results in significant changes in blood pressure, indicating that the molecular clock

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2625-252X ts in the field.Covers multiple organ systems and cellular p.This book presents cutting edge methods that provide insights into the pathways by which salt and water traverse cell membranes and flow in an orchestrated fashion amongst the many compartments of the body. It focuses on a number of molecu

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Renal Medullary Functional Architecture and the Urinary Concentrating Mechanism,tification of significant functional interactions between tubules and interstitium. Defects in expression and function of a number of the medullary membrane transporters are known to underlie several human disorders associated with Na and water imbalance and have provided new insights into the urine concentrating mechanism.

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Use of Genetic Models to Study the Urinary Concentrating Mechanism,ter we provide a brief overview of genetic mouse model generation, and then summarize findings in transgenic and knockout mice pertinent to our understanding of the urinary concentrating mechanism, focusing predominantly on mice in which expression of specific renal transporters or receptors has been deleted.