Titlebook: Skin Aging & Cancer; Ambient UV-R Exposur Ashish Dwivedi,Neeraj Agarwal,Amit Kumar Tripathi Book 2019 Springer Nature Singapore Pte Ltd. 20

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Bioinformatics in Skin Cancer: A System Biology Approach to Understanding the Molecular Mechanisms cinogens has also increased the cancer burden in humans. Skin cancer is mainly associated with the DNA damage because of the prolonged exposure to UV radiation. Several structural changes, mutations and amplifications of oncogenes have been reported in skin cancer. The continuous development of bioi

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Monitoring the Genotoxic Potential of Sunlight and DNA Photoprotection of Sunscreen,n health, need to be better understood. DNA molecule has been identified as the main cellular target of solar UV-R, and the UV-induced DNA damage is considered the initiating step of important biological process, such as the development skin cancers and aging. This chapter focuses on the use of phys

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Book 2019ontinually reconstructs itself to ensure its viability, integrity, and ability to provide protection for the body. This protection can be compromised by the aging of the skin which ultimately promotes skin inflammation, impaired wound repair, and increased risk of skin cancer. The book entails mecha

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Chemiexcitation of Melanin and Melanoma Pathogenesis, by chemiexcitation of melanin pigment. Melanin gets excited to higher energy level after UV exposure by the production of free radicals like nitric oxide and superoxide. Thus, this excitation of melanin pigments is responsible factor for damage of DNA after exposure of longer wavelength of UVA which ultimately promotes melanoma pathogenesis.

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Ultraviolet Radiation-Induced Immunomodulation: Skin Ageing and Cancer, include free radical-induced cell injury, direct and indirect DNA damage, genetic mutations, etc. We have elaborated on the risk factors and causes of UV-induced skin ageing and cancer in details. We have also enlisted the preventive measures that can minimize the UV-mediated chronic pathologies including premature ageing and cancer.