Titlebook: Single-cell Sequencing and Methylation; Methods and Clinical Buwei Yu,Jiaqiang Zhang,Xiangdong Wang Book 2020 The Editor(s) (if applicable)

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Single Cell Sequencing in Cancer Diagnostics,cribe current possibilities for implementation of single cell sequencing of malignomas in clinic, as well as discuss hands-on practical advice for single cell routine diagnostics that allows for full delineation of tumor clonality.

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Single-Cell Sequencing of T cell Receptors: A Perspective on the Technological Development and Tranomplished by the expression of T cell receptors (TCR) which are required to be diverse and adaptable in order to accommodate the various and vast number of antigens presented on the MHCs. Thus, determining TCR repertoires of effector T cells is necessary to understand the immunological process in re

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DNA Methylation in Pulmonary Fibrosis,sis. This chapter illustrates alteration of DNA methylation in pulmonary fibrosis as a predictive or prognostic factor. Treatment with the DNA methylation inhibitors will be an emerging anti-fibrosis therapy, although we are still in the pre-clinical stage of using epigenetic markers as potential ta

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Methylation of Inflammatory Cells in Lung Diseases,s, although the molecular mechanisms by which target genes are methylated and regulated in lung diseases remain unclear. Most of epigenetic studies on DNA methylation of target genes in lung diseases mainly demonstrated the correlation of DNA methylation of target genes with the levels of other corr

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Research Advances on DNA Methylation in Idiopathic Pulmonary Fibrosis,ogressive fibrosis and dysfunctions that lead to respiratory failure. Several factors may impact the progress of IPF, including age, cigarette smoking, and dusts, of which genetic and epigenetic factors mainly contribute to lung tissue fibrosis. DNA methylation is one of epigenetic processes that oc

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