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Titlebook: Single-cell Sequencing and Methylation; Methods and Clinical Buwei Yu,Jiaqiang Zhang,Xiangdong Wang Book 2020 The Editor(s) (if applicable)

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Clinical Significance of P16 Gene Methylation in Lung Cancer,ed stages with a poor prognosis which often miss the best treatment opportunities. Thus, identifying biomarkers for minimally invasive detection and prognosis of early stage disease is urgently needed. Genetic and epigenetic alterations that promote tumorigenesis and metastasis exist in multiple can
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PI3K Isoform-Selective Inhibitors in Cancer,ell metabolism, cell survival, and a multitude of other functions. There are multiple isoforms of PI3K that can be broken down into three categories: class I, II, and III. Each isoform has at least one subunit that helps with the functionality of the isoform. Mutations found in the PI3K isoforms are
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Single Cell Sequencing in Cancer Diagnostics,ly a decade been standard clinical practice to analyze the genome and expression of the genes of patients. The results are reflected directly in the treatment plan for the patient, in targeted medical inventions. This specialized mode of diagnostics has been restricted to account for averaged trends
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Emerging Strategies for Therapeutic Antibody Discovery from Human B Cells,quisite specificity and high potency while maintaining a desirable safety profile, having been matured and tolerized within human patients. However, the discovery of these antibodies presents important challenges, since the B cells encoding therapeutic antibodies can be rare in a typical blood draw
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