Titlebook: Single Domain Antibodies; Methods and Protocol Dirk Saerens,Serge Muyldermans Book 2012 Springer Science+Business Media, LLC 2012 Heavy cha

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Selection of VHH Antibody Fragments That Recognize Different Aβ Depositions Using Complex Immune Libonstructed from animals immunized with the antigen of interest. An important point of consideration when making immune libraries is the availability of an appropriate antigen sources. When available, often either the amount is not sufficient for immunization or it is expensive to obtain. To overcome

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Overview and Discovery of IgNARs and Generation of VNARs that they exhibit considerable stability and are readily produced in heterologous protein expression systems. In this chapter, I describe the history and discovery of IgNARs, the development of VNAR biotechnology, and highlight important factors in VNAR protein production.

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Selection of VHHs Under Application Conditionsr selection individual antibodies need to be tested in appropriate screening assays, again taking into account the conditions under which the antibody should bind to the target and induce the desired effect.

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Isolation and Characterization of , Toxin-Specific Single-Domain Antibodiesma immunization and recombinant antibody/phage display technology approaches and for further characterization of the VHHs with respect to toxin-binding affinity and specificity and the conformational nature of their epitopes.

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From Whole Monoclonal Antibodies to Single Domain Antibodies: Think Smallapter, we will review the major steps of the therapeutic antibodies history and we will highlight the enormous potential of antibody fragments, either used as multiunits such as bispecific antibodies, single units, or as cell modifiers such as intrabodies or cell surface-expressed molecules.

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