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Titlebook: Simian Immunodeficiency Virus; Norman L. Letvin,Ronald C. Desrosiers Book 1994 The Editor(s) (if applicable) and The Author(s), under excl

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书目名称Simian Immunodeficiency Virus
编辑Norman L. Letvin,Ronald C. Desrosiers
视频video
丛书名称Current Topics in Microbiology and Immunology
图书封面Titlebook: Simian Immunodeficiency Virus;  Norman L. Letvin,Ronald C. Desrosiers Book 1994 The Editor(s) (if applicable) and The Author(s), under excl
描述Interest in the lentivirus subfamily of retroviruses has greatly intensified due to the realization that HIV-1 and HIV-2 are members of this previously obscure group. Related lentiviruses have now been isolated from sheep, goats, horses, cattle, cats, monkeys, and humans. This issue of CTMI is devoted to the lentiviruses of nonhuman primates, referred to as simian immunodeficiency viruses (SIVs). The SIVs provide valuable tools for our quest to understand and control the HIVs, which are obviously important new human pathogens. Included in this volume are discussions of the distribution and molecular phylogeny of the SIVs and their use as animal models for the study of AIDS pathogenesis, and the chapters clearly illustrate how SIV models are contributing to our understanding of the ability of host immune responses to control infection at least temporarily and the ability of virus to evade these host immune defenses.
出版日期Book 1994
关键词AIDS; HIV; T cell; antibody; immune response; immunodeficiency; infection; pathogenesis; pathology; protein; p
版次1
doihttps://doi.org/10.1007/978-3-642-78536-8
isbn_softcover978-3-642-78538-2
isbn_ebook978-3-642-78536-8Series ISSN 0070-217X Series E-ISSN 2196-9965
issn_series 0070-217X
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
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Conserved Framework of Envelope Glycoproteins Among Lentiviruses,HIV-1, as well as that lentiviruses, comparisons of amino acid sequences among variou isolates have shown that envelope glycoproteins consist of a succession of variable domains which are bordered by conserved domains, most likely determining a conserved spatial framework organization (A. et al. 1986; M. et al. 1990).
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MHC of Nonhuman Primates, MHC products involved in the recognition of the virus is crucial. Indeed, in outbred populations, definition of the cellular immune response to a pathogen cannot be carried out without the knowledge of the MHC products involved.
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Comparison of Regulatory Features Among Primate Lentiviruses,sed (reviewed in D. 1990; M. et al. 1992b). From this perspective, we can operationally categorize the primate lentiviruses into four groups, represented by (a) HIV-1 and SIV.; (b) SIV., SIV., and HIV-2; (c) SIV.; and (d) SIV. (D. 1990; M. et al. 1992b).
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Book 1994y obscure group. Related lentiviruses have now been isolated from sheep, goats, horses, cattle, cats, monkeys, and humans. This issue of CTMI is devoted to the lentiviruses of nonhuman primates, referred to as simian immunodeficiency viruses (SIVs). The SIVs provide valuable tools for our quest to u
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