Titlebook: Signal Transduction in Mast Cells and Basophils; Ehud Razin,Juan Rivera Book 1999 Springer-Verlag New York, Inc. 1999 Activation.apoptosis

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Book 1999hways of action work are the focus of much present day research into allergy and inflammation. This book focuses primarily on the molecular mechanisms that govern mast cell and basophil cell biology and function, as well as providing a comprehensive summary of the field of signal transduction and al

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The Regulation of Mast Cell and Basophil Development by the Kit Ligand, SCF, and IL-3e large topics to which many groups have made important contributions. In this chapter, we review current understanding of the effects of two cytokines, the kit ligand, stem cell factor (SCF), and interleukin-3 (IL-3), on mast cell and basophil development. Several other chapters in this book also a

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The c-, Receptor and the , Transcription Factor: Two Important Molecules for Mast Cell Developmenttranscription factors that integrate the signals from growth factors and activate lineage-specific genes.. For the development of mast cells, the signals generated by binding of stem cell factor (SCF) to the c-kit receptor tyrosine kinase (KIT) is essential. Loss-of-function mutations at either the

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Mouse and Rat Models of Mast Cell Development height of helminth infection are phenotypically different from the MC residing in the skin of uninfected animals.. The biochemical basis for these variations was subsequently shown to be the different neutral proteases. and proteoglycans. stored in the secretory granules of the MC. Because hybrid M

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Factors That Affect Human Mast Cell and Basophil Growthr of cytokines, and have comparable amounts of histamine. It has been assumed that the two cells share a common progenitor, or that one cell originates from the other. This notion is unlikely to be correct because basophils appear to represent a terminally differentiated cell rather than a periphera

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Signal Transduction by Cytokinesl. These signals determine the number and type of mast cells in particular tissues in health and disease, as well as regulating their state of activity. Most of these extracellular stimuli are sensed by cell-surface receptors that activate the complex networks of intracellular signals which ultimate

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Mast Cell Apoptosis and Its Regulationof mast cells in these tissues under normal conditions is relatively constant.. Mast cell hyperplasia occurs, however, in several conditions including host responses to parasites and neoplasia; in tissue repair and fibrosis; and in chronic inflammatory conditions associated with the pathology of dis