Titlebook: Signal Transduction in Mast Cells and Basophils; Ehud Razin,Juan Rivera Book 1999 Springer-Verlag New York, Inc. 1999 Activation.apoptosis

Agility

EXTOL

FcεRI Signaling in Specialized Membrane Domainsetion of granules containing inflammatory mediators from these cells, as well as the production of other inflammatory agents. The earliest detectable events following receptor aggregation involve the tyrosine phosphorylation of FcεRI within immunoreceptor tyrosine-based activation motifs (ITAMs). Th

Hippocampus

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The Role of Protein Phosphatases in Cell Signaling by the High-Affinity Receptor for Immunoglobulin ins. The protein kinases that catalyze protein phosphorylations and the protein phosphatases which catalyze dephosphoryla-tions therefore represent crucial points of control in the coordination of cell activity.

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Protein Kinase C and Early Mast Cell Signalsnly thought that the activity associated with this family of kinases is important for both the homeostasis of an organism and the regulation of its responses to environmental stimuli. The response of PKC isozymes to a stimulus can be beneficial (as in the activation of normal cellular functions) or

Gerontology

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Signaling Pathways That Regulate Effector Function: Perspectivesn a motif with the amino acid sequence (D/E)x.Yx.Lx.Yx.(L/I) that is essential for cell activation.. This immunoreceptor tyrosine-based activation motif (ITAM) is also present in the subunits of the T-cell and B-cell antigen receptors.. The aggregation of these receptors results in phosphorylation o

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Phosphoinositide-Derived Second Messengers in FcεRI Signaling: PI-3 Kinase Products Control Membraneto changes in adhesive properties, cell shape, and surface topography, and to the synthesis of lipid mediators of inflammation and of cytokines. Key features of this signaling cascade were summarized by contributors to an earlier volume. and are updated in other chapters in this volume. In brief, cr

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Mast Cell Apoptosis and Its Regulationnclude IL-3 and the c-. ligand stem cell factor (SCF) as the principal growth-promoting cytokines. However, less is known about the mechanisms that regulate the viability of mature mast cells and permit mast cell apoptosis.