Titlebook: Signal Transduction in Mast Cells and Basophils; Ehud Razin,Juan Rivera Book 1999 Springer-Verlag New York, Inc. 1999 Activation.apoptosis

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Phosphoinositide-Derived Second Messengers in FcεRI Signaling: PI-3 Kinase Products Control Membrane mast cell substrates are immunoreceptor tyrosine-based activation motifs (ITAMs) found in the FcεRI γ- and β-subunit cytoplasmic domains.. Lyn-mediated receptor subunit phosphorylation in turn permits the recruitment and activation of Syk tyrosine kinase. and the phosphorylation of multiple protein substrates..

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FcεRI Signaling in Specialized Membrane Domainsis initial phosphorylation step, referred to here as ., is mediated by the protein tyrosine kinase (PTK) Lyn, and it is regulated by unidentified tyrosine phosphatases. The phosphorylated ITAMs recruit SH-2 domain-containing signaling proteins, including Syk, a ZAP-70-related PTK that binds the phosphorylated receptor γ-chains.

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Protein Kinase C and Early Mast Cell Signalsdetrimental (as in the induction of neoplasia). What determines whether a response is beneficial or detrimental is not understood, but recent studies on isozyme function and substrate specificity have begun to provide some clues as to how PKC is activated and what effect(s) this activity has on functional responses.

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Mast Cell Inhibitory Receptors of the Immunoglobulin Superfamilyast cells seconds to minutes after the initiation of activation. Lipid-derived mediators, such as leukotriene (LT)C. and prostaglandin (PG)D., are synthesized de novo from phospholipids by the concerted action of enzymes of the 5-lipoxygenase and cyclooxygenase pathways, respectively.

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