| 书目名称 | Sigma Receptors: Their Role in Disease and as Therapeutic Targets |
| 编辑 | Sylvia B. Smith,Tsung-Ping Su |
| 视频video | |
| 概述 | Very few books about Sigma receptors, yet the field regarding Sigma receptors has exploded.A comprehensive treatise on this unique protein.Of significant relevance to very severe diseases (blindness, |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | .Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.. |
| 出版日期 | Book 2017 |
| 关键词 | Drug Target; Molecular Chaperone; Neurodegeneration; Neuroprotection; Sigma 1 Receptor; Receptors |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-50174-1 |
| isbn_softcover | 978-3-319-84335-3 |
| isbn_ebook | 978-3-319-50174-1Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | Springer International Publishing AG (outside the USA) 2017 |
发表于 2025-3-21 20:09:51
