Titlebook: Sigma Receptors: Their Role in Disease and as Therapeutic Targets; Sylvia B. Smith,Tsung-Ping Su Book 2017 Springer International Publishi

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Sigma Receptors and Substance Use Disorders, of abuse, including alcohol, are able to produce significant neuroplastic changes responsible for the profound disturbances shown by drug addicted individuals. The current lack of efficacious pharmacological treatments for substance use disorders has encouraged the search for novel and more effecti

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Stimulation of the Sigma-1 Receptor and the Effects on Neurogenesis and Depressive Behaviors in Miculation antagonizes depressive-like behaviors in animal models, but molecular mechanisms underlying this effect remain unclear. Here, we focus on the effects of Sig-1R ligands on hippocampal neurogenesis and depressive-like behaviors. Sig-1R stimulation also enhances CaMKII/CaMKIV and protein kinase

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,Role of σ1 Receptors in Learning and Memory and Alzheimer’s Disease-Type Dementia,nists have been tested in a variety of pharmacological and pathological models of learning impairments in rodents these last past 20 years. Their anti-amnesic effects have been explained by the wide-range modulatory role of σ. receptors on Ca. mobilizations, neurotransmitter responses, and particula

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Sigma-1 Receptor in Motoneuron Disease,Multiple etiopathogenic mechanisms appear to contribute in the development of ALS, including glutamate excitotoxicity, oxidative stress, protein misfolding, mitochondrial defects, impaired axonal transport, inflammation and glial cell alterations. The Sigma-1 receptor is highly expressed in motoneur

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,The Sigma-1 Receptor–A Therapeutic Target for the Treatment of ALS?,ord motor neuron activation occurs, in part, via large ventral horn cholinergic synapses called C-boutons/C-terminals. Chronic excitation of motor neurons and alterations in C-terminals has been associated with Amyotrophic Lateral Sclerosis (ALS). The S1R has an important role in regulating motor ne

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The Role of Sigma1R in Mammalian Retina,performed in the late 1990s that provided evidence of the presence of Sigma1R in various ocular tissues. It then describes work from a number of labs concerning the location of Sigma1R in several retinal cell types including ganglion, Müller glia, and photoreceptors. The role of Sigma1R ligands in r

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Peeking into Sigma-1 Receptor Functions Through the Retina,vorable experimental model system. The exquisite architecture of the mammalian retina features layered and intricately wired neurons supported by non-neuronal cells. Ganglion neurons, photoreceptors, as well as the retinal pigment epithelium, are susceptible to degeneration that leads to major retin

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Book 2017ny degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types.  It’s putative role in degenerative neuronal diseases including amyotrophic l