| 书目名称 | Sialo-Xenoantigenic Glycobiology | | 副标题 | Molecular Glycobiolo | | 编辑 | Kwon-Ho Song,Cheorl-Ho Kim | | 视频video | | | 概述 | Latest research on Sialo-Xenoantigenic Glycobiology.Focuses on carbohydrate antigens including sialic acids as xenoantigenic determinant in human.Written by leading experts in the fiel | | 丛书名称 | Sungkyunkwan University Outstanding Research | | 图书封面 |  | | 描述 | .Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid–based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of t | | 出版日期 | Book 2013 | | 关键词 | Carbohydrate Antigens; Sialic Acids; Sialo-Xenoantigenic Glycobiology | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-34094-9 | | isbn_softcover | 978-3-642-43443-3 | | isbn_ebook | 978-3-642-34094-9Series ISSN 2195-3546 Series E-ISSN 2195-3554 | | issn_series | 2195-3546 | | copyright | Springer-Verlag Berlin Heidelberg 2013 |
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发表于 2025-3-21 17:22:13
