Titlebook: Short-Term Tests for Chemical Carcinogens; H. F. Stich (Head),R. H. C. San (Chief) Conference proceedings 1981 Springer-Verlag New York In

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Detection of DNA-Modifying Agents by Analyzing the Lesions Introduced into Purified PM2 DNAsuring directly the lesions introduced into DNA rather than the biological consequences of DNA damage. The double-stranded circular DNA of phage PM2 is incubated with the agent to be tested, separated from the unreacted chemical, and then tested for DNA lesions by methods which involve simple incuba

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DNA Repair Synthesis (UDS) as an , and , Bioassay to Detect Precarcinogens, Ultimate Carcinogens, anassessing DNA repair synthesis has been used for several purposes. These include detection of mutagenic and carcinogenic activities of chemicals or complex mixtures, detection of DNA repair inhibitors, estimation of organotropic actions of carcinogens, and identification of individuals with DNA repa

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Multi-well Assay for Unscheduled DNA Synthesis Using Human Diploid Fibroblastsests for mutagenic activity (Kilbey .., 1977; Montesano .., 1976) has greatly facilitated the task of identifying mutagenic substances, and since it has been demonstrated that many mutagens are also carcinogens (McCann.., 1975), these substances may also be carcinogenic. Short-term tests for mutagen

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