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Titlebook: Selective Activation of Drugs by Redox Processes; G. E. Adams,A. Breccia,P. Wardman Book 1990 Plenum Press, New York 1990 cancer.chemother

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Improved Treatment of Tumours in vivo by Combining the Bioreductive Drug RSU-1069, Hydralazine and ypoxic cells.. Although resistant to radiation it has been found that these cells are also sensitive to certain drugs. and hyperthermia.. As a result, attempts are now being made to actually increase the level of tumour hypoxia before subsequent exposure to these hypoxic cell cytotoxic agents.
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Mechanisms of Activation of Mitomycin C and AZQ in Aerobic and Hypoxic Mammalian Cells,capillaries or by fluctuating blood flow.. A number of electron affinic drugs are preferentially reduced to more active forms in the hypoxic regions because the low levels of oxygen are ineffective in back oxidizing the drug to its less active parent form..
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