Titlebook: Selective Activation of Drugs by Redox Processes; G. E. Adams,A. Breccia,P. Wardman Book 1990 Plenum Press, New York 1990 cancer.chemother

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NATO Science Series A:http://image.papertrans.cn/s/image/864307.jpg

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https://doi.org/10.1007/978-1-4615-3768-7cancer; chemotherapy; clinical research; drug; protein; proteins; radiation oncology; research

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978-1-4613-6679-9Plenum Press, New York 1990

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Overview: 978-1-4613-6679-9978-1-4615-3768-7

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Characteristics of Hypoxic Cells that Enhance their Susceptibility to Chemical Injury,ly common occurrence that can predispose cells to irreversible injury from chemical, physical and biological agents. The purpose of this brief review is to summarize some of our recent studies on cellular responses to neahypoxia that enhance susceptibility to chemical injury.

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The Role of DNA Damage in the Bioreductive Action of 2-Nitroimidazoles,erably more cytotoxic than the parent compound. Such bioreduction is critically dependant upon such factors as oxygen tension, the redox potential of the agent and temperature, the latter reflecting the enzymatic steps. Oxygen acts by protecting against formation of reduced metabolites of the agents

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