Titlebook: Scientific Issues in Quantitative Cancer Risk Assessment; Suresh H. Moolgavkar Book 1990 Springer Science+Business Media New York 1990 DNA

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Cancer Dose-Response Models Incorporating Clonal Expansion,of mathematical models of carcinogenesis that have a potential to be used for cancer dose-response modeling are discussed. The two classes of models considered are (1) a general version of the two-stage model by Moolgavkar and colleagues [12, 13], henceforth called the MVK model, and (2) a clone pro

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Interindividual Variation in Human Chemical Carcinogenesis: Implications for Risk Assessment,tumor suppressor genes. Chemical carcinogens are generally activated enzymatically to electrophiles that form covalently bound carcinogen-DNA adducts. Detoxifying enzymes are competing with the activating enzymes for these procarcinogenic chemical substrates. Wide person to person variations in thes

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