Titlebook: Risk Assessment of Prenatally-Induced Adverse Health Effects; Diether Neubert,Robert J. Kavlock (Director),Jane Conference proceedings 19

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Scientific Basis for Risk Assessment (Reproductive Toxicity) for Pesticides as Practiced by the Bunds law regulations call for decisions based on safety standards which imply acceptable degrees of risk, without providing any precise definition of permissible degrees of risk. The margin of judgement provided by such legislation confers upon public health agencies the difficult task of making discre

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Statistical Problems (and Some Solutions) Associated with Testing for Effects in Developmental ToxicKalter 1974; Staples and Haseman 1974; Becker 1974; Haseman and Hogan 1975). Much of the recent biostatistical work on testing has been on devising powerful statistical tests that reflect the proper choice for the unit of observation. This paper will review some of the statistical problems posed by

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IntroductionRisk assessment of prenatally-induced adverse health effects is still a considerable problem, and it will continue to be so for the next decade.

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A Call for Increased Flexibility in Current Teratogenicity TestingThe testing of new drugs and chemicals for the potential risk they might pose for the human population is a very difficult proposition. In the field of developmental toxicity this task is more difficult due to the added complexity of species differences in embryogenesis and the placental interface.

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Specific and Non-Specific Developmental EffectsEmbryo damage can arise in a number of different ways. Essentially two possibilities exist:

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Scientific Basis for Risk Assessment (Reproductive Toxicity) for Medicinal Products as Practiced in It is often said that regulatory agencies keep their secrets about the interpretation of risk, and risk assessment, and we shall try to find out if this is really true.