书目名称 | Risk Assessment of Prenatally-Induced Adverse Health Effects |
编辑 | Diether Neubert,Robert J. Kavlock (Director),Jane |
视频video | http://file.papertrans.cn/831/830636/830636.mp4 |
图书封面 |  |
描述 | Since the thalidomide (Contergan) tragedy about 30 years agothe inductionof prenatally-induced morphological orfunctional defects has been an areaof extensive research.Risk assessment of prenatally-induced adverse health effectsis still a difficult task from both experimental data aswell asfrom observations in humans. In the contributions tothis book three majoraspects are dealt with:- Quantitative extrapolations of experimental datato the situation possibly relevant for man.- The significance for a risk assessment with respect to man of minor or rare structuralabnormalities observed in experimental studies- The future need toassess congenital dysfunctions (e.g. of the hormone or the immune system)beside the present evaulation of structural defects.Limitations aswell as gaps of the present knowledge in thisarea of basic and applied research are pointed out. Sincethe results of prenatally-induced lesions may manifestthemselves not only pre- but often not beforelatepostnatally, numerous aspects of structural and functionalabnormaldevelopment must be studied in experimental andclinical investigations. |
出版日期 | Conference proceedings 1992 |
关键词 | Embryopharmacology; Embryopharmakologie; Embryotoxicology; Embryotoxikologie; research |
版次 | 1 |
doi | https://doi.org/10.1007/978-3-642-77753-0 |
isbn_softcover | 978-3-642-77755-4 |
isbn_ebook | 978-3-642-77753-0 |
copyright | Springer-Verlag Berlin Heidelberg 1992 |