Titlebook: Retinoids; Advances in Basic Re C. E. Orfanos (Director),O. Braun-Falco (Chairman) Conference proceedings 1981 Springer-Verlag, Berlin Heid

不如乐死去

妨碍

Studies in Reproductive Toxicology and Mutagenicity with Ro 10-9359rabbits to investigate the influence on the embryo and fetus and on the general reproductive performance on these animals. Furthermore, the in vivo and in vitro experiments were performed to test for chromosome breaking or point mutation inducing activity of this compound.

栖息地

IRS

Effects of Oral Retinoid on Dermal Components in Human and Animal Skinentiation of epithelial cells (2,15, 19,22). Though some experimental observations have led to the suggestion that also the dermis may be a target tissue for retinoids, little attention has been paid to dermal changes under oral retinoid therapy. Thus, the effects of Ro 10-9359 on the dermis remained almost entirely unknown.

原告

Retinoid-binding Proteins and the Plasma Transport of Etretinate (Ro 10-9359) in Man In plasma, the naturally occurring retinyl esters are associated with the lipoproteins until they reach the liver (9). Retinol is released from the liver bound equimolarily to the retinol-binding protein (RBP) (6) and cell-surface receptors for RBP are involved in the delivery of the vitamin to epithelia (14).

staging

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