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Titlebook: Retinoids; Advances in Basic Re C. E. Orfanos (Director),O. Braun-Falco (Chairman) Conference proceedings 1981 Springer-Verlag, Berlin Heid

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Studies in Reproductive Toxicology and Mutagenicity with Ro 10-9359rabbits to investigate the influence on the embryo and fetus and on the general reproductive performance on these animals. Furthermore, the in vivo and in vitro experiments were performed to test for chromosome breaking or point mutation inducing activity of this compound.
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Cytogenetic Studies in Patients Treated with Oral Retinoid Ro 10-9359ge, it must be regarded as potentially harmful in terms of mutagenicity and carcinogenicity. The fact that retinoic acid and its analogs have shown to prevent chemical carcinogenesis (1,10), does not necessarily exclude a carcinogenic effect of these compounds. We therefore determined the rate of ch
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Retinoid-binding Proteins and the Plasma Transport of Etretinate (Ro 10-9359) in Man In plasma, the naturally occurring retinyl esters are associated with the lipoproteins until they reach the liver (9). Retinol is released from the liver bound equimolarily to the retinol-binding protein (RBP) (6) and cell-surface receptors for RBP are involved in the delivery of the vitamin to epi
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