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Titlebook: Retinoids; Advances in Basic Re C. E. Orfanos (Director),O. Braun-Falco (Chairman) Conference proceedings 1981 Springer-Verlag, Berlin Heid

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Retinoids: New Developments in Their Mechanism of Action as Related to Control of Proliferative Disets the acquisition of neoplastic properties … It is highly probable that the epithelium of gland ducts, respiratory mucosa, and genitourinary tract have secretory functions, so that we conclude that the [retinoid] deficiency results in loss of specific chemical functions of the epithelia concerned,
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Conference proceedings 1981yet unknown storage site. Investigation of metabolism of Tigason in rats and humans revealed 19 different bio­ transformation products thus far, most of them appearing in the urine in low amounts (20010 of dose). A few of them (mainly the acid Ro 10-1670) after conjugation to glucuronic acid are exc
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d at some yet unknown storage site. Investigation of metabolism of Tigason in rats and humans revealed 19 different bio­ transformation products thus far, most of them appearing in the urine in low amounts (20010 of dose). A few of them (mainly the acid Ro 10-1670) after conjugation to glucuronic acid are exc978-3-642-68025-0978-3-642-68023-6
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ltaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was possible. Using Nonlin parameter estimates of the single-dose data, one is able to predict the decline in plasma levels of parent drug following cessation of a 10 days multiple dosing regi
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In Vivo Immunostimulating Properties of Two Retinoids: Ro 10-9359 and Ro 13-6298elial tissues (12,13); they possess an antiproliferative effect caused by a reduction of DNA synthesis (9); they can also prevent the development of tumors induced in vivo by chemical carcinogen or even reverse the malignant transformation (1, 10, 15). Many mechanisms could be involved in the antitu
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Vitamin A Transport and Delivery and the Mechanism of Vitamin A Toxicityrecently as a general term that includes both the natural forms of vitamin A and synthetic analogs, with or without biological activity, of retinol. Vitamin A is necessary for the support of growth, health, and life of higher animals. In the absence of vitamin A, animals will cease to grow and, in t
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