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Titlebook: Research in Computational Molecular Biology; 17th Annual Internat Minghua Deng,Rui Jiang,Xuegong Zhang Conference proceedings 2013 Springer

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Roy Ronen,Nitin Udpa,Eran Halperin,Vineet Bafnaby the fusion of the appropriate DNA regulatory sequences to reporter genes have led to the identification of a great number of DNA control elements that constitute eukaryotic promoters. Recently, transcription factors that interact with specific DNA control elements have been purified and the cDNAs
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Dong-Yeon Cho,Teresa M. Przytycka to tumors, the direct killing of tumor cells, and direct int- ference with tumor growth. In this context, gene transfer systems, tumor-specific expression vectors, and novel therapeutic genes 978-0-89603-843-1978-1-59259-086-5Series ISSN 1543-1894 Series E-ISSN 1940-6037
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SEME: A Fast Mapper of Illumina Sequencing Reads with Statistical Evaluation, two parts corresponding to the seed and extension step, and the composite result provides an approximate overall reliability estimate of each mapping. We compare SEME with some existing mapping methods on several data sets, and SEME shows better performance in terms of both running time and mapping
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eALPS: Estimating Abundance Levels in Pooled Sequencing Using Available Genotyping Data,purious associations. Fortunately, it is often the case that the genotype data of at least some of the individuals in the pool is known. Here, we propose a method (eALPS) that uses the genotype data in conjunction with the pooled sequence data in order to accurately estimate the proportions of the s
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Analysis of Metabolic Evolution in Bacteria Using Whole-Genome Metabolic Models,o its current habitat in the human colon is also analysed. Our analysis shows that the capability to utilize N-Acetyl-neuraminic acid as a carbon source has been gained, rather than having been present in the . ancestor, as has the capability to synthesise phthiocerol dimycocerosate which could pote
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Detecting Protein Conformational Changes in Interactions via Scaling Known Structures,er methods for the same purpose. On 20 complexes, we obtained an average iRMSD of 1.55Å, which compares favorably with the average iRMSD of 1.94Å in the predictions from FiberDock. Compared with ZDOCK, our results are of 0.35Å less in average iRMSD on the medium difficulty group, and 0.81Å less on t
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UniNovo : A Universal Tool for , Peptide Sequencing,vo is superior to other tools for ETD spectra and superior or comparable to others for CID and HCD spectra. UniNovo also estimates the probability that each reported reconstruction is correct, using simple statistics that are readily obtained from a small training dataset. We demonstrate that the es
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Efficiently Identifying Significant Associations in Genome-Wide Association Studies, informative SNPs, or proxies, across the genome are tested. Based on their observed associations, our approach locates the regions which may contain significant SNPs and only tests additional SNPs from those regions. We show through simulations and analysis of real GWAS datasets that the proposed t
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