Titlebook: Research in Computational Molecular Biology; 17th Annual Internat Minghua Deng,Rui Jiang,Xuegong Zhang Conference proceedings 2013 Springer

Tartar

Itamar Eskin,Farhad Hormozdiari,Lucia Conde,Jacques Riby,Chris Skibola,Eleazar Eskin,Eran Halperinresponses. This strategy, now known as genetic or DNA immunization, was first described by Johnston et al. in 1992. They reported that bombardment of murine skin with an expression plasmid encoding human growth hormone coated onto microscopic gold particles using a gene gun resulted not only in the

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Ali A. Faruqi,William A. Bryant,John W. Pinneythese approaches using an IGF-I antisense RNA strategy of treatment. Insulin-like growth factor I (IGF-I) and IGF-II have pivotal roles in cell proliferation and development (for review see 1–4). The preponderance of peptide synthesis and activity occur during fetal development. Protein synthesis is

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Harpoon

Jesper Jansson,Chuanqi Shen,Wing-Kin Sung(herceptin) for breast cancer or Iressa (gefitinib) for non-small cell lung cancer among others are limited by lack of efficacy, cellular resistance, and toxicity. Dose escalation and combination therapies designed to overcome resistance and increase efficacy are limited by a narrow therapeutic inde

Expurgate

Kyowon Jeong,Sangtae Kim,Pavel A. Pevzneris book chapter we describe the selection and characterization of DNA aptamers specific to the human epidermal growth factor receptor 2 (ERBB2/HER2), an oncogenic tyrosine kinase. First, a DNA aptamer library is applied and ERBB2-specific aptamers are selected using SELEX. Binders are subcloned into

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命令变成大炮

Xiaowen Liu,Shawna Hengel,Si Wu,Nikola Tolić,Ljiljana Pasa-Tolić,Pavel A. Pevzner is raising new prospects on the outcome of an effective anticancer treatment. It is well known that the success of gene transfer to cells and subsequent expression is strictly affected by the vector manufacturing process. Therefore, several downstream methods have been proposed to achieve high quan

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Alina Munteanu,Raluca Gordânion relationships. Though success with DNA transfer was reported as early as 1962 (Szybalska and Szybalski, 1962), widespread use of this method had to await later developments. On the basis of a method developed by Graham and van der Eb (1973), Wigler .. (1977) and Maitland and McDougall (1977) suc

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Sergey Nurk,Anton Bankevich,Dmitry Antipov,Alexey Gurevich,Anton Korobeynikov,Alla Lapidus,Andrey Prduring their sexual reproductive phase, cell-to-cell transfer of single-stranded DNA has been demonstrated (Lederberg, 1947; Wollman .., 1956). In addition, DNA isolated from one genotype could stably change the phenotype of another bacterium (Avery .., 1944). Similarly, the infection of bacteria by