Titlebook: Relaxing and Contracting Factors; Biological and Clini Paul M. Vanhoutte Book 1988 The Humana Press Inc. 1988 Dilatation.Drogen.blood vesse

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Heterogeneity in Endothelium-Dependent Relaxations Acute, Chronic, and Evolutionary Modulations,ed on the characterization of endothelium-dependent responses and on the identification of the substance(s) that mediates such responses in mammalian blood vessels. It soon became obvious that the amplitude and direction of endothelium-dependent responses to a given agonist varied among vessels deri

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Endothelium-Dependent Regulation of Resting Levels of Cyclic GMP and Cyclic AMP and Tension in Pulm by intracellular cyclic GMP. A variety of “nitrogen oxide-containing vasodilators” such as organic nitrate and nitrite esters, inorganic and organic nitroso compounds, 5-nitrosothiols, and nitric oxide (NO) all activate the soluble heme-containing enzyme guanylate cyclase, elevate levels of cyclic

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Endothelium-Dependent Reponses of Cerebral Arteries,sence of their endothelial cells (Vanhoutte and Katusic, 1986). Large cerebral arteries contribute to the total vascular resistance in the brain (Heistad and Kontos, 1983); thus endothelium-dependent phenomena may actively participate in regulation of cerebral blood flow. This chapter will review br

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Endothelium-Dependent Responses in Large Arteries and in the Microcirculation,small artery diameter. As a result of the now classic discovery of endothelium-derived relaxing factor (EDRF) by Furchgott and Zawad-zki (1980), any discussion of the physiology or pathology of vascular reactivity must consider the integrity and function of the cells lining the intimal surface.

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Book 1988t Furchgott and colleagues (see Chapter 1) of the evidence of endothelium-dependent relaxation in isolated arteries, there are ever­ increasing numbers of vascular physiologists and pharmacologists who are scraping away the endothelium to look into its role in cardiovascular con­ trol. And the more

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0 by Robert Furchgott and colleagues (see Chapter 1) of the evidence of endothelium-dependent relaxation in isolated arteries, there are ever­ increasing numbers of vascular physiologists and pharmacologists who are scraping away the endothelium to look into its role in cardiovascular con­ trol. And