Titlebook: Regulatory Toxicology; Franz-Xaver Reichl,Michael Schwenk Reference work 2021Latest edition Springer Nature Switzerland AG 2021 environmen

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Aims and Mission of Regulatory Toxicologyestimation of the risk at a certain exposure. Up to now, the risk of genotoxic carcinogens at a certain exposure concentration is estimated by linear extrapolation of the dose–response curve. Further, to set priorities the margin of exposure (MOE) or margin of safety (MOS) can be calculated by compa

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Integration of Advanced Technologies into Regulatory Toxicologypproach for specific endpoints. The Tox21 concept, which is relying on advanced technologies, using human stem cells, multiorgan-chips and in silico models will most probably prove that the future of toxicology will be in vitro.

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Quality Assurance in Toxicologyhese objectives can be reached by the implementation of appropriate Quality Assurance (QA) systems as an important part of the Quality Management (QM). The major characteristics and differences of the more important quality assurance systems are presented in this chapter.

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Reference work 2021Latest editionoxicological data generation and decision-making. It includes a number of new chapters that cover recent developments, such as regulation of nanoparticles, illicit designer drugs or tattoos..The Handbook deals comprehensively with the safety-ensuring methods and concepts employed for acute and chron