Titlebook: Regulatory T Cells and Clinical Application; Shuiping Jiang Book 2008 Springer-Verlag New York 2008 Asthma.T cell.Transplantation.allergy.

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Regulatory T Cells and the Control of Auto-Immunity: From day 3 Thymectomy to FoxP3+ Regulatory T Ce was shown in the late sixties that some CD4+ T cells in normal mice were capable of suppressing autoimmunity. Efforts to characterize this autoimmune-suppressive CD4+ T cell population led to the identification of CD25 as a constitutional marker. Using this marker, it became possible to separate re

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The Role of IL-2 in the Development and Peripheral Homeostasis of Naturally Occurring CD4,CD25,Foxp3nting a wide variety of autoimmune diseases. Along with Foxp3, the high affinity IL-2R represents one of the better characterized molecules of T. cells. Current data support models where the IL-2/IL-2R interaction, primarily through STAT5 activation, controls T. cell development in the thymus and th

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IL-2 Signaling and CD4+ CD25+ Regulatory T Cellsitially identified as a T cell growth factor, loss of function experiments clearly showed that it rather acts as a gatekeeper of immune homeostasis and tolerance. It is now widely accepted that the major non-redundant function of IL-2 is the maintenance of naturally occurring CD25+ Foxp3+ regulatory

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Molecular Signalling in T Regulatory Cellsentional T cells. Their importance in controlling a wide range of immune responses, including autoimmune disease, cancer and transplantation tolerance is well established. Treg cells differ from T effector cells in many aspects, including their capacity to proliferate, produce cytokines, and express