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Titlebook: Regulatory T Cells and Clinical Application; Shuiping Jiang Book 2008 Springer-Verlag New York 2008 Asthma.T cell.Transplantation.allergy.

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发表于 2025-3-21 19:07:46 | 显示全部楼层 |阅读模式
书目名称Regulatory T Cells and Clinical Application
编辑Shuiping Jiang
视频video
概述Covers one of the hottest topics in immunology today.Compiles recent developments in T cell immunobiology and clinical applications.Will have broad appeal to both researchers and clinicians.Includes s
图书封面Titlebook: Regulatory T Cells and Clinical Application;  Shuiping Jiang Book 2008 Springer-Verlag New York 2008 Asthma.T cell.Transplantation.allergy.
描述.A major process of rediscovery has taken place in the field of Cellular Immunology over the past 12 years—subsets of T lymphocytes exist that are specifically dedicated to regulation or as it should be more appropriately termed suppression of all aspects of immune responses. ..It was only after Prof. Sakaguchi identified the CD25 antigen in 1995 as a marker for a major population of T cells that had suppressor functions both in vitro and in vivo that the resurgence in the regulatory T cell area could begin. ..The regulatory T cells field has grown dramatically over the past decade. It is now impossible to read a journal that does not contain numerous papers whose titles deal with regulatory T cells. More importantly, it is also difficult to submit a new research grant proposal in any area of immunologic research that does not include a section on analysis on the contribution of regulatory T cells to the subject matter under study. ..Regulatory T cells can be best thought of today as "teenagers" ready to take on all the challenges of complex immune responses. In ten years, the field will certainly be more mature, and manipulation of regulatory T cell function by cellular biotherapy
出版日期Book 2008
关键词Asthma; T cell; Transplantation; allergy; autoimmune disease; cancer; cell therapy; immune regulation; immun
版次1
doihttps://doi.org/10.1007/978-0-387-77909-6
isbn_softcover978-1-4419-2670-8
isbn_ebook978-0-387-77909-6
copyrightSpringer-Verlag New York 2008
The information of publication is updating

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Regulatory T Cells and the Control of Auto-Immunity: From day 3 Thymectomy to FoxP3+ Regulatory T Cents. Anomalies in FOXP3 gene are responsible for the development of an autoimmune and inflammatory disease in humans and rodents characterized by a deficiency in the development and function of CD25+CD4+ regulatory T cells. These recent findings provide clear evidence that Foxp3+CD25+CD4+ regulatory
发表于 2025-3-23 05:24:54 | 显示全部楼层
FoxP3 and Regulatory T Cellscells into Tregs in peripheral lymphoid tissue essentially depends on TGF-β and is inhibited by costimulation. In fact retinoic acid, produced by some dendritic cells, helps the conversion process by counteracting the negative impact of costimulation on the conversion process. Since AP-1 is produced
发表于 2025-3-23 08:23:22 | 显示全部楼层
Thymic and Peripheral Generation of CD4, Foxp3, Regulatory T Cellsg-repertoire appears to be shaped in the thymus through a two-step positive selection process, one step occurring in the thymic cortex and the other in the medulla, combined with reduced sensitivity to negative selection. Also peripheral and therefore fully mature conventional T cells can, under cer
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