Titlebook: Regulation of Immune Gene Expression; Marc Feldmann,Andrew McMichael Book 1986 The Humana Press Inc. 1986 Antigen.DNA.chromosome.evolution

Etymology

Functional Characterization of Several Steric Domains of the Murine Thy-1 and LFA-1 Moleculesctional sites of these molecules is to develop mAb identifying spatially distinct antigenic epitopes of the same structure and to evaluate the effects of these reagents on the function of T-cell clones or hybridomas. We summarize in this communication our studies on the topology-function relationship of the murine Thy-1 and LFA-1 molecules.

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AMITY

A Fusion Gene of Immunoglobulin and T cell Receptor DNA Segments in a Chromosome 14 Inversion of T-cmality in this cell line results in the formation of a chimaeric gene comprising both immunoglobul in and T cell receptor DNA segments. The possible relationship of this fused gene to tumour aetiology is discussed.

CRAB

A Chromosomal Inversion Generates a Functional T Cell Receptor β Chain Geneptamer, a non-conserved spacer sequence of 12 or 23 nucleotides and a conserved A/T rich nonamer. As in immunoglobulin genes, DNA rearrangement occurs only when one gene segment has a 12 base pair spacer sequence and the second has a 23 nucleotide spacer sequence.

Atheroma

Gene Organization and Recombination Hot Spots in the Murine Major Histocompatibility ComplexII molecules, I-A and I-E, are guidance molecules for most helper T cells. Alpha and beta chains of class II molecules are encoded in the MHC, while for class I molecules only the α chain is. The β chain, called β.-microglobulin, is encoded by a gene located on chromosome 2.

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Glucose

The T-Cell Receptor/T3 Complexf the proteolytically processed antigen on the surface of antigen presenting cells. Antigen and receptor interaction triggers T-cell proliferation and thus results in an increase of the number of antigen specific T-cells. In the case of cytotoxic T-cells, receptor-antigen interaction also induces the lysis of target cells.

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