| 书目名称 | Regulation of Immune Gene Expression | | 编辑 | Marc Feldmann,Andrew McMichael | | 视频video | | | 丛书名称 | Experimental Biology and Medicine | | 图书封面 |  | | 描述 | This book encompasses the proceedings of a conference held at Trinity College, Oxford on September 21-25, 1985 organized by a committee comprised of Drs. M. Crumpton, M. Feldmann, A. McMichael, and E. Simpson, and advised by many friends and colleagues. The immune response gene workshops that took place were based on the need to understand why certain experimental animal strains were high responders and others were low responders. It was assumed that identification of the immune response (Ir) genes and definition of their products would explain high and low responder status. Research in the ensuing years has identified the Ir gene products involved in antibody responses as the la antigens, or MHC Class II antigens. These proteins are now well defined as members of the immunoglobulin gene superfamily, and their domain structure is known. Epitopes have been defined by multiple mono clonal antibodies and regions of hypervariability identified. Their genes have been identified and cloned. The basic observation of high and low responsive ness to antigen is still not understood in mechanistic terms, however, at either the cellular or molecular level. This is because the rate of progres | | 出版日期 | Book 1986 | | 关键词 | Antigen; DNA; chromosome; evolution; gene expression; genes; genetics; molecular biology; recombination; tran | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4612-5014-2 | | isbn_softcover | 978-1-4612-9399-6 | | isbn_ebook | 978-1-4612-5014-2 | | copyright | The Humana Press Inc. 1986 |
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发表于 2025-3-21 19:58:30
