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Titlebook: Recombinant Antibodies for Cancer Therapy; Methods and Protocol Martin Welschof,Jürgen Krauss Book 2003 Humana Press 2003

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发表于 2025-3-21 19:34:39 | 显示全部楼层 |阅读模式
书目名称Recombinant Antibodies for Cancer Therapy
副标题Methods and Protocol
编辑Martin Welschof,Jürgen Krauss
视频video
概述Includes supplementary material:
丛书名称Methods in Molecular Biology
图书封面Titlebook: Recombinant Antibodies for Cancer Therapy; Methods and Protocol Martin Welschof,Jürgen Krauss Book 2003 Humana Press 2003
描述Since the advent of hybridoma technology more than two decades ago, numerous antibodies have entered the clinical setting as potent therapeutic agents. Their repeated application in humans, however, is limited by the development of human antimouse antibodies (HAMA) in the recipient, leading to allergic re- tions against the foreign murine protein and rapid neutralization. To circumvent these limitations many new antibodies have recently been tailored through recombinant antibody technology. The initial clinical data show encouraging results, thus demonstrating the potential of these new therapeutic agents. The purpose of Recombinant Antibodies for Cancer Therapy is to present a collection of detailed protocols in recombinant antibody technology. It is pri- rily addressed to scientists working on recombinant antibodies as well as cli- cians involved with antibody-based therapies. As with other volumes of this series, we placed the main focus on providing detailed protocols describing procedures step-by-step. Moreover, each protocol supplies a troubleshooting guide containing detailed information on possible problems and hints for pot- tial solutions. Antibody technology is a subject
出版日期Book 2003
版次1
doihttps://doi.org/10.1385/1592593348
isbn_softcover978-1-61737-250-6
isbn_ebook978-1-59259-334-7Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightHumana Press 2003
The information of publication is updating

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Generation of Antibody Molecules Through Antibody Engineeringances in the fields of cell biology and clinical diagnostics (.). However, in spite of their early promise, monoclonal antibodies (MAbs) were largely unsuccessful as therapeutic reagents resulting from insufficient activation of human effector functions and immune reactions against proteins of murin
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Application of Recombinant Antibodies in Cancer Patientsnical trials since the early 1980s. Clinical outcomes were generally poor (.–.), with the notable exception of marked tumor responses, including long-term remissions of patients with malignant B-cell lymphoma who were treated with patient-specific antiidiotypic antibodies (.–.). The main factors res
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DNA Immunization as a Means to Generate Antibodies to Proteins for a number of intractable diseases. Their uses include identification and cloning of new genes from expression libraries, purification and structure-function analysis of proteins, histochemical localization of proteins, as diagnostic markers and/or probes, as targeting agents to deliver drugs and
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