Titlebook: Recent Developments in Mass Spectrometry in Biochemistry and Medicine; Volume 1 Alberto Frigerio Book 1978 Plenum Press, New York 1978 Mass

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Distribution in Brain Areas of Carbamazepine and Carbamazepine-10,11-epoxide in 6-Hydroxydopamine Pory animals. Increased susceptibility to electroconvulsions has been reported in mice and rats treated with drugs which deplete brain monoamines, such as reserpine, a-methylparatyrosine and parachlorophenylalanine (1–4). These findings, together with reports on the anticonvulsant activity of two ami

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Specific Ion Detection of Aryloxy Beta Blocking Drugs for Metabolic Fate Determinations-Applicationlso increases. An improved insight into the biological fate of these drugs is necessary to be able to understand the actions they produce, both beneficial and maybe also toxic. It is known, for example, that several beta-blocking drugs produce pharmacologically active metabolites. A metabolites of p

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,Studies on the Measurement of α-Methyldopa in Pregnant Women and the Newborn Infant, disposition in the pregnant woman and newborn infant..The assay involves derivatisation (tris-trifluoroacetyl-n- -butyl ester) of the drug in plasma and urine and its quantification by selected ion monitoring in the electron impact mode of ions m/e 454 for α-methyldopa and m/e 457 for the internal

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GC and MS in the Identification of Metabolites of 5-(1-methylethyl)-1-methyl-2-nitro-l ,-imidazole main metabolites and the unchanged drug were identified with the contribution of radio gas chromatography and mass spectrometry. Preliminary mass spectral correlations with some other nitroimidazoles are given.

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,Comparative , Metabolism of Δ,-tetrahydrocannabinol (Δ,-THC), cannabidiol (CBD) and cannabinol (CBNtography on Sephadex LH-20 and examined byGC-MS as trimethylsilyl (TMS), Me-TMS, methyloxime (MO)-TMS, .H., derivatives and by reduction with LiALD.. Δ.-THC was extensively metabolised to mono-, di-, and tri-ols, hydroxy and dihydroxy ketones, acids, hydroxy and dihydroxy acids and dihydro compounds

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Chemical Ionization Techniques for the Analysis of Labile Compounds: 1,3-bis-(2-chloroethyl)-1-nitrromatography (hplc) is an effective technique for these analyses because only mild sample handling conditions are used. Hplc applications are limited, however, by the lack of a sensitive universal detection system. Direct probe chemical ionization (ci) techniques also employ mild sample handling con

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