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Titlebook: Recent Advances in the Epidemiology and Prevention of Gallstone Disease; Proceedings of the S L. Capocaccia,G. Ricci,L. Lalloni Conference

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Prevalence of gallstone disease in 18 Italian population samples: first results from the MICOL studye [1–5], it was only with the advent of ultrasonography that epidemiological studies could be conducted on a large number of subjects with some degree of reliability. These include, among others, a few previous Italian studies [6–7].
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The outcome of gallstone disease in symptomatic and asymptomatic patientstoms and the clinical difficulties associated with an accurate diagnosis of upper abdominal gastrointestinal disease. For many years, patients with gallstones, symptomatic or silent, were urged to undergo prompt cholecystectomy thus depriving epidemiologists the opportunity to study the course of the disease.
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Prevalence of gallstone disease in thalassaemia minorit. However, this being a condition which is found all over the world, it is possible to calculate that there are no fewer than 5 million carriers of the thalassaemic trait in the Mediterranean area alone [7].
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Risk factors for gallstone disease: genetic, ethnic and environmental factors multifactorial. Much has been learned in recent years about factors in bile associated with cholesterol gallstone formation; however the reasons for the rising incidence of gallstones remain unknown. There is evidence to support the existence of all 3 factors which are the subject of the present discussion.
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The GREPCO studies: methodology, prevalence and incidence datad. In addition, the causal role of possible risk factors had been evaluated in only a few prospective studies, which were not primarily devoted to the study of gallstones and where cases were mostly subjects already cholecystectomized.
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