Titlebook: Recent Advances in Nervous System Toxicology; Corrado L. Galli,Luigi Manzo,Peter S. Spencer Conference proceedings 1988 Plenum Press, New

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Neurotoxic Effects of Metals and Their Interactionsfects, so far as we can judge the issues at the present moment, and it is only apparently by chance that two very dissimilar metals, arsenic and thallium, produce clinical and pathological changes that have a great deal in common. This is the product of a purely accidental involvement of the same im

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Organophosphorus Compounds1.5 billion, is projected to increase (Ecobichon, 1982a). Several books and reviews have been published on their chemistry, metabolism, toxicology and mechanism of action (O’Brien, 1960; 1967; Heath, 1961; Koelle, 1963; Casida, 1964; Karczmar et al., 1970; O’Brien and Yamamoto, 1970; Eto, 1974; Mats

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The Delayed Polyneuropathy Caused by Some Organophosphorus Estersl and peripheral nervous system including the well known acute cholinergic syndrome, as results from the inhibition of acetylcholinesterase (AChE) at nerve endings .. Some bicyclic phosphate esters cause convulsive seizures, not related to AChE inhibition, but possibly acting as . γ-aminobutyrate an

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Receptor Binding Techniques in Neurotoxicologygh the theoretical basis of radioligand binding assays, the experimental methodologies and the basic processes of interpretation of binding data will be briefly considered, the reader is referred to other publications for more detailed theoretical and practical reviews (Peck and Kelner, 1983; Yamamu

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Biochemical Contributions to Neurotoxicology and increasing production of toxic waste products is significantly altering a series of global characteristics. These include irreversible ecological damage and the prospect of significant climatic changes.

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Membrane Effects of Neurotoxic Chemicalsht about by a rapid, transient increase in the permeability of the membrane for sodium, resulting in an inward sodium current, followed by an increase in the potassium permeability, resulting in an outward potassium current. As a result, the membrane potential temporarily reverses sign and an action potential is conducted along the nerve fibre.

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